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Energy
Biological aging refers to the process by which our bodies deteriorate over time at a molecular level, often differing from our chronological age. Factors such as lifestyle, genetics, and environmental influences play significant roles in determining our biological age. Recently, there has been a surge of interest in diets and lifestyle interventions that could potentially slow down or even reverse this aging process. One such controversial diet gaining attention is the very low-calorie ketogenic diet (VLCKD).
A VLCKD is a highly restrictive diet that involves severe calorie restriction (often under 800 calories per day) and a high intake of fat. This diet is designed to put the body into a metabolic state called ketosis, where it burns fat for energy instead of carbohydrates. While popular for rapid weight loss, its long-term safety and efficacy have been subjects of debate.
Recent studies have explored the potential of the VLCKD in reversing biological aging. A groundbreaking study published in 2025 in the journal Nutrients examined how obesity affects biological aging and whether this accelerated aging could be slowed or reversed by following a VLCKD. The researchers analyzed two groups: individuals at a normal weight and those with obesity, comparing their biological ages using three different epigenetic clocks.
While the VLCKD may offer promising results, it is not the only diet linked to anti-aging benefits. Other dietary interventions, such as the Mediterranean diet and methylation-supportive diets, have also been studied for their potential to reverse biological aging.
The Mediterranean diet emphasizes whole foods like fruits, vegetables, legumes, lean proteins, and dairy, while restricting red meat, processed foods, and alcohol. Renowned for its heart health benefits and cognitive preservation, this diet has been recommended as one of the healthiest worldwide.
These diets focus on supporting DNA methylation patterns that are crucial for biological aging. A case series of six women who followed an 8-week methylation-supportive program, including diet, sleep, exercise, and supplements, showed an average reduction in biological age of 4.6 years.
While these diets show promise, there are challenges to consider:
The quest for anti-aging strategies has led scientists to explore novel dietary approaches that may reverse biological aging. The VLCKD, despite its controversy, presents intriguing possibilities in slowing down biological aging, especially for individuals with obesity. However, caution is advised due to potential health risks and the need for further research to solidify these findings. As we continue to unravel the mysteries of aging, dietary interventions—along with lifestyle changes—hold the potential to revolutionize our understanding of healthspan and lifespan.
