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Health Care
Fibrotic diseases are chronic, often terminal conditions affecting millions worldwide. These diseases, such as idiopathic pulmonary fibrosis (IPF), involve the formation of excessive scar tissue, leading to organ failure in various tissues including the lungs, liver, and kidneys. Traditional treatments primarily focus on managing symptoms and moderately slowing disease progression by targeting inflammatory mediators or growth factors. However, these methods do not provide a cure for fibrotic diseases.
In a significant step forward, Tribune Therapeutics, a biotech company based in Stockholm and Oslo, has secured €37 million in seed and Series A funding. This investment will propel Tribune's innovative approach to treating fibrotic diseases by targeting the root causes of scar tissue formation.
Tribune Therapeutics was founded on groundbreaking discoveries related to the CCN family of proteins, key drivers of scar formation. These proteins have historically been challenging to target comprehensively. The company's lead program, TRX-44, is designed to mimic CCN5, an endogenous protein that naturally blocks the pro-fibrotic effects of other CCN family members, such as CTGF/CCN2 and WISP1/CCN4. This approach aims to combat a broader set of fibrotic diseases without the toxic side effects seen in less targeted therapies.
The €37 million in funding includes a €23 million Series A round led by LifeArc Ventures, with participation from both new and existing investors. In addition to LifeArc, Industrifonden and Investinor are joining as new investors for the Series A round. Seed investors Novo Holdings, HealthCap, Innovestor’s Life Science Fund, and Inven2 also contributed to this significant financing round.
As part of the agreement, LifeArc's Chris Baker and Industrifonden's Jonathan Ilicki will join Tribune Therapeutics' board, contributing their experience and expertise to guide the company’s future development.
This funding is crucial for advancing Tribune's pipeline of therapies, particularly preparing TRX-44 for its first clinical trials. The progressive nature of fibrotic diseases makes the need for effective treatments urgent.
Tribune Therapeutics' approach to fibrosis treatment represents a beacon of hope for patients suffering from these debilitating conditions. Fibrotic diseases, such as IPF, are not just chronic; they are often fatal. The current standard of care offers limited relief, focusing primarily on symptom management rather than disease reversal.
The successful funding round for Tribune Therapeutics marks an important milestone in the fight against fibrotic diseases. As Tribune progresses towards clinical trials, its innovative approach has the potential to revolutionize how we treat these conditions, offering new hope for patients worldwide.
